儿科过敏 & 免疫学

的 Division of Allergy, 免疫学, and Rheumatology cares for adult and pediatric patients with disorders of the immune system. Our patients have an unusual susceptibility to allergies and 哮喘, 自身免疫, autoinflammation, 或严重, recurrent or opportunistic infections. We offer the most advanced diagnostics and treatments in the country. Our faculty members include leaders in the field and provide excellent clinical care and conduct cutting-edge research. We operate two ACGME-certified programs to train future leaders in the fields of Allergy and 免疫学, and 儿科风湿病学.

的 program has a long and cherished history beginning in 1969 when Dr. E. Richard Stiehm served as the first chief of the division. Faculty in the division have discovered the mechanistic causes of numerous immune diseases in children, developed uses of immune globulin in the prevention and treatment of infections, and pioneered methods for bone marrow and cord-blood transplants. In the early years of HIV, 免疫学 division faculty were instrumental in recognizing AIDS in children and in leading efforts to prevent maternal transmission of HIV to fetuses.

过敏的程序

Our allergy clinic has a focus on food allergy, allergic rhinitis and conjunctivitis, 哮喘, 药物过敏. Additionally, we care for children with 哮喘 and other respiratory disorders. State-of-the-art skin testing and blood tests are performed in the clinic to provide answers about allergic sensitization. Food challenges are performed to definitively assess the risk of immediate-type food allergies.

Delayed-type gastrointestinal diseases (including Food Protein Induced Enterocolitis Syndrome, 乳糜泻, and eosinophilic gastroenteritis) are followed with our colleagues from Gastroenterology. Spirometry testing and allergy testing are used to facilitate the management of 哮喘 with our colleagues from the Pulmonary clinic.

Our clinic has the most sophisticated reagents for assessing drug allergies and can provide options for treatment, including desensitization. 的se efforts improve the quality and stewardship of antibiotics used across the hospital system.

免疫程序

Our immunology clinic focuses on primary immunodeficiency disease, also called genetic immune diseases. 的se “mystery” diseases confer a susceptibility to severe, recurrent or opportunistic infections, 自身免疫, 和autoinflammation. 我们关心 for antibody deficiencies such as Common Variable Immune Deficiency (CVID) and more serious defects of the adaptive immune system, including T cell defects such as Combined Immunodeficiency (CID) and severe combined immune deficiency (SCID). We are recognized by the state as a major referral center for Southern California for management of newborn babies who screen positive for SCID.

We employ whole exome and genome sequencing as well as cutting-edge genetic validation to diagnose novel or rare immune diseases. Treatments include immunoglobulin replacement infusions (subcutaneous or intravenous), immunomodulatory medicines, anti-inflammatory medicines, and advanced cellular therapies, including hematopoietic stem cell transplantation and gene therapy.

Diagnostic 服务 include:

• Allergy skin testing (prick testing, patch testing)
• Measurements of lung function (spirometry)
• Specific IgE testing (RAST, Immunocap, ISAC)
• 成像:胸部 & sinus X-rays and CT scans
• 食品和药品挑战
• Nutritional evaluation of patients with food allergies
• Comprehensive evaluation of the immune function
• In-clinic ultrasound of the joints to monitor arthritis
• Genetic testing for immune diseases
• T细胞检测
• 疫苗的挑战
• Innate immune function testing

治疗方法包括:

• Immunotherapy (Allergy shots)
• Immunoglobulin treatment (IVIG)
• 免疫调节
• Ultrasound-guided joint injections
• 药物脱敏
• Disease-specific management
• Allergen elimination diet